2-(Hydroxymethyl)chroman → HCID 22036549, compound

HRID 1789734Notes

Reaction equation

HRID 1789734 reaction equation
Cl[C:2]1[C:11]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[O:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:21][CH2:20][CH:19]1[CH2:28][OH:29]>>[O:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:21][CH2:20][CH:19]1[CH2:28][O:29][C:2]1[C:11]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 27948162-(Hydroxymethyl)chromanHCID 38468372-CHLORO-3-PIPERAZIN-1-YL-QUINOXALINE

Product 1

HCID 22036549HCID 22036549, compoundYield 23%

Procedure

The title product was prepared according to the procedure described in Example 162, Step 2, starting from 2-chloro-3-(1-piperazinyl)quinoxaline (described in Example 162. Step 1) and 3,4-dihydro-2H-chromen-2-ylmethanol.* The product was obtained as a yellow amorphous substance: yield 23%; mp 202-204° C.; HRMS m/z calcd for C13H16N4O2(M)+376.1899, found 376.1899. Anal. (C22H24N4O2.HCl) H; C: calcd, 61.32; found. 60.7; N: calcd, 13.00; found 13.5.

Workup

  1. custom* The product was obtained as a yellow amorphous substance

Sources & evidence

ORD record
ord-111ec1813902481295d106ac16594a7a
Source dataset
uspto-grants-2006_07
Patent number
US07071180B2

Reaction notes

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