2-(difluoromethyl)-1H-1,3-benzodiazole → 2-(6-Amino-2-difluoromethylbenzimidazol-1-yl)-4,6-dimorpholinopyrimidine

Participants

Reaction Steps

In accordance with the procedure of the Example 1 except that 2-difluoromethylbenzimidazole in (1) of the Example 1 was replaced by 2-difluoro-6-nitrobenzimidazole, a mixture of 2-(2-difluoromethyl-5-nitrobenzimidazol-1-yl)-4,6-dimorpholinopyrimidine with 2-(2-difluoromethyl-6-nitrobenzimidazol-1-yl)-4,6-dimorpholinopyrimidine was obtained. In accordance with the procedure of (3) of the Example 8, using 0.92 g (2.0 mmol) of this mixture, 0.76 g (yield: 88%) of the titled compound was obtained as colorless crystals.

Provenance & Evidence