2-(difluoromethyl)-1H-1,3-benzodiazole → HCID 66669741, compound

Participants

Reaction Steps

In accordance with the procedure of the Example 4 except that 2-difluoromethylbenzimidazole in (1) of the Example 4 was replaced by 2-difluoromethyl-5-tert-butyldimethyl-silyloxybenzimidazole, obtained was 2-(2-difluoromethyl-5-tert-butyldimethylsilyloxybenzimidazol-1-yl)-4-(cis-2,3-dimethylmorpholino)-6-morpholino-1,3,5-triazine. 120 mg (0.22 mmol) of the obtained compound dissolved in THF (2 ml) was added with a solution of tetrabutylammoniumfluoride (1 M) in THF (0.5 ml) and stirred at room temperature for 30 minutes. The reaction solution was poured into water and extracted with ethyl acetate. The separated organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography to obtain 75 mg (yield: 79%) of the titled compound as colorless crystals.

Provenance & Evidence