Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1789832Generated: October 30, 2026

2-acetylsulfanylmethyl-3-(6-[N,N-bis(tert-butoxycarbonyl)amino]-5-methyl-pyridin-3-yl)-propionic acid ethyl ester → 3-(6-Amino-5-methyl-pyridin-3-yl)-2-mercaptomethyl-propionic acid

https://huagongshe.com/reaction/1789832

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-acetylsulfanylmethyl-3-(6-[N,N-bis(tert-butoxycarbonyl)amino]-5-methyl-pyridin-3-yl)-propionic acid ethyl esterHCID 54221100—
SolventHydrochloric AcidHCID 313—
Product3-(6-Amino-5-methyl-pyridin-3-yl)-2-mercaptomethyl-propionic acidHCID 10130759115.7%

Reaction Steps

2-Acetylsulfanylmethyl-3-(6-[N,N-bis(tert-butoxycarbonyl)amino]-5-methyl-pyridin-3-yl)-propionic acid ethyl ester (17 mg, 0.034 mmol) was dissolved in conc. HCl (3.0 mL). The solution was heated to reflux for 1 h. Concentration under reduced pressure gave the title compound (8.9 mg, 100%) as the hydrochloride salt.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07071175B1
Source datasetuspto-grants-2006_07
ORD IDord-03fea22a728046a797595b16b44adb1c
Source noteuspto-grants-2006_07