HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-acetylsulfanylmethyl-3-(6-[N,N-bis(tert-butoxycarbonyl)amino]-4-methyl-pyridin-3-yl)-propionic acid ethyl ester → 3-(6Amino-4-methyl-pyridin-3-yl)-2-mercaptomethyl-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-acetylsulfanylmethyl-3-(6-[N,N-bis(tert-butoxycarbonyl)amino]-4-methyl-pyridin-3-yl)-propionic acid ethyl ester | HCID 57094567 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-(6Amino-4-methyl-pyridin-3-yl)-2-mercaptomethyl-propionic acid | HCID 9794536 | 114.8% |
Reaction Steps
2-Acetylsulfanylmethyl-3-(6-[N,N-bis(tert-butoxycarbonyl)amino]-4-methyl-pyridin-3-yl)-propionic acid ethyl ester (36 mg, 0.072 mmol) was dissolved in conc. HCl (3.0 mL). The solution was heated to reflux for 1 h. Concentration under reduced pressure gave the title compound (18.7 mg, 98%) as the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071175B1 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-d41aba1fce454adcb3f51d2dde176afd |
| Source note | uspto-grants-2006_07 |