Hydrochloric Acid → 3-(6-Amino-pyridin-3-yl)-2-mercaptomethyl-butyric acid

Participants

Reaction Steps

Conc. hydrochloric acid (4 mL) was added to 2-acetylsulfanylmethyl-3-(6amino-pyridin-3-yl)-butyric acid ethyl ester (104 mg, 0.253 mmol) under argon. The reaction was heated to reflux for 5 h and then concentrated under reduced pressure to give a diastereomeric mixture of the title compound (61 mg, 92%) as the hydrochloride salt.

Provenance & Evidence