Methanol → N-[2-(7-methyl-1H-indazol-5-yl)-1-[1-[(2-methyl-4-pyridinyl)methyl]imidazol-2-yl]ethyl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide

HRID 178992Notes

Reaction equation

HRID 178992 reaction equation
[CH3:47][OH:48].[Cl:1][c:2]1[n:3][c:4]([CH3:46])[cH:5][c:6]([CH2:8][n:9]2[c:10]([CH:14]([CH2:15][c:16]3[cH:17][c:18]4[cH:19][n:20][nH:21][c:22]4[c:23]([CH3:25])[cH:24]3)[NH:26][C:27](=[O:28])[N:29]3[CH2:30][CH2:31][CH:32]([N:35]4[C:36](=[O:45])[NH:37][c:38]5[cH:39][cH:40][cH:41][cH:42][c:43]5[CH2:44]4)[CH2:33][CH2:34]3)[n:11][cH:12][cH:13]2)[cH:7]1.[Pd:49]>>[cH:2]1[n:3][c:4]([CH3:46])[cH:5][c:6]([CH2:8][n:9]2[c:10]([CH:14]([CH2:15][c:16]3[cH:17][c:18]4[cH:19][n:20][nH:21][c:22]4[c:23]([CH3:25])[cH:24]3)[NH:26][C:27](=[O:28])[N:29]3[CH2:30][CH2:31][CH:32]([N:35]4[C:36](=[O:45])[NH:37][c:38]5[cH:39][cH:40][cH:41][cH:42][c:43]5[CH2:44]4)[CH2:33][CH2:34]3)[n:11][cH:12][cH:13]2)[cH:7]1

Participants

4

Reactant 3

HCID 887MethanolHCID 23938PalladiumHCID 11422298N-(1-(1-((2-Chloro-6-methylpyridin-4-yl)methyl)-1H-imidazol-2-yl)-2-(7-methyl-1H-indazol-5-yl)ethyl)-4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxamide

Product 1

HCID 11478962N-[2-(7-methyl-1H-indazol-5-yl)-1-[1-[(2-methyl-4-pyridinyl)methyl]imidazol-2-yl]ethyl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide

Sources & evidence

ORD record
ord-2c4e10a4adbb4fdea027a1ea6e5c1fec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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