Formaldehyde → HCID 53851245, compound

Participants

Reaction Steps

To a mixture of 2-(2-tert- butoxycarbonylamino-thiazol-5-ylmethyl)-malonic acid monoethyl ester (94 mg; 0.27 mmol), a 36% aqueous solution of formaldehyde (36 μl; 1.2 mmol), CH2Cl2 (0.2 mL) and water (0.2 mL) was added at 0° C. diethyl amine (30 μl; 0.40 mmol). The reaction mixture was stirred at room temperature overnight, poured onto ice-water and extracted with CH2Cl2. The combined organic phases were washed with 5% NaHCO3, dried and concentrated to yield 2-(2-tert-butoxycarbonylamino-thiazol-5-ylmethyl)-acrylic acid ethyl ester (69 mg, 80.9%).

Provenance & Evidence