Sodium Hydroxide → HCID 10309281, compound

HRID 1789970Notes

Reaction equation

HRID 1789970 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]2[C@@H:21]3[CH2:22][N:23](C(OC(C)(C)C)=O)[CH2:24][CH2:25][C@@H:20]3[N:13]3[CH2:14][CH2:15][N:16]([CH3:19])[C:17]([CH:18]=1)=[C:12]23.[OH-].[Na+]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]2[C@@H:21]3[CH2:22][NH:23][CH2:24][CH2:25][C@@H:20]3[N:13]3[CH2:14][CH2:15][N:16]([CH3:19])[C:17]([CH:18]=1)=[C:12]23

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 86591145HCID 86591145, compound

Product 1

HCID 10309281HCID 10309281, compoundYield 80%

Procedure

The hydrochloride salt of the title compound was prepared from tert-butyl (6bR,10aS)-5-(2,4-dichlorophenyl)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate (50 mg) using the deprotection procedures described in Example 275, Step B. The salt formed was free-based with 6 N NaOH to give the title compound (31 mg, 80%).

Workup

  1. customThe salt formed

Sources & evidence

ORD record
ord-c9ff34fccf9a40a6b3e88db116cbc8cf
Source dataset
uspto-grants-2006_07
Patent number
US07071186B2

Reaction notes

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