反应详情

温度

0 °C

To a mixture of 36 ml of 2-fluorobenzylzinc chloride (0.5 M sol. in tetrahydrofuran) and 0.008 g of dichlorobis(triphenylphosphine)palladium(II) stirred at 0° C. was added dropwise via a syringe 2.14 ml of cyclohexanecarbonyl chloride. Afterwards, the reaction mixture was stirred at r.t. for 4 h, quenched with an aqueous saturated solution of ammonium chloride (25 ml), extracted with 20 ml of EtOAc, which was dried (Na2SO4) and evaporated to dryness in vacuo affording 3.52 g of the title compound as a crude, which could be used in the following step without further purification.

1. stirringAfterwards, the reaction mixture was stirred at r.t. for 4 h
2. customquenched with an aqueous saturated solution of ammonium chloride (25 ml)
3. extractionextracted with 20 ml of EtOAc, which
4. dry with materialwas dried (Na2SO4)
5. customevaporated to dryness in vacuo