Ethyl 2,4-dioxo-1-(piperidin-1-yl)piperidine-3-carboxylate → [1,1']Bipiperidinyl-2,4-dione

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Reaction Conditions

Reaction Steps

Ethyl 2,4-dioxo-1,1′-bipiperidine-3-carboxylate (11.36 g, 42.38 mmol, Example 14) was dissolved in 10% AcOH (200 mL) and heated at reflux 125° C. for 1 h. The cooled reaction was evaporated, and the residue was purified by flash chromatography using a gradient of 9:1 to 1:1 CH2Cl2/acetone, to give the product as a yellow viscous oil (6.4 g, 22% yield for the two last steps).

Provenance & Evidence