反应详情

1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-5-ylamine and 3-(4-phenoxy-phenyl)-propionic acid were processed as described in Example 17 to provide the title compound. MS (DCI/NH3) MS m/z 455 (M+H)+; 1H NMR (500 MHz, DMSO-d6) δ ppm 1.83 (m, 2 H), 1.99 (m, 2 H), 2.79 (t, J=7.64 Hz, 2 H), 2.96 (t, J=7.49 Hz, 2 H), 3.06 (m, 2 H), 3.52 (m, 2 H), 3.71 (q, J=5.61 Hz, 2 H), 4.74 (t, J=6.24 Hz, 2 H), 6.95 (m, 4 H), 7.11 (m, 1 H), 7.30 (m, 2 H), 7.37 (m, 3 H), 7.43 (m, 1 H), 7.68 (m, 1 H), 8.31 (s, 1 H), 9.67 (br s, N H).