3-(4-Phenylphenyl)prop-2-enoic acid → HCID 11247588, compound

HRID 1790109Notes

Reaction equation

HRID 1790109 reaction equation
[N:1]1([CH2:6][CH2:7][N:8]2[C:16]3[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:18]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:23]=[CH:22][C:21]([CH:24]=[CH:25][C:26](O)=[O:27])=[CH:20][CH:19]=1>>[C:18]1([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:19]=[CH:20][C:21](/[CH:24]=[CH:25]/[C:26]([NH:17][C:13]2[CH:12]=[C:11]3[C:16](=[CH:15][CH:14]=2)[N:8]([CH2:7][CH2:6][N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[N:9]=[CH:10]3)=[O:27])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 254923-(4-Phenylphenyl)prop-2-enoic acidHCID 113107771-(2-Pyrrolidin-1-YL-ethyl)-1H-indazol-5-ylamine

Product 1

HCID 11247588HCID 11247588, compound

Procedure

1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-5-ylamine and 3-biphenyl-4-yl-acrylic acid were processed as described in Example 17 to provide the title compound. MS (DCI/NH3) MS m/z 437 (M+H)+; 1H NMR (500 MHz, DMSO-d6) δ ppm 1.84 (m, 2 H), 1.99 (m, 2 H), 3.06 (m, 2 H), 3.53 (m, 2 H), 3.72 (m, 2 H), 4.76 (t, J=5.93 Hz, 2 H), 6.91 (m, 1 H), 7.40 (m, 1 H), 7.50 (m, 2 H), 7.64 (m, 2 H), 7.75 (m, 7 H), 8.18 (s, 1 H), 8.31 (s, 1 H), 9.56 (br s, N H)

Sources & evidence

ORD record
ord-9d6c0d884bcc4bc0ba574d7ce4f212d5
Source dataset
uspto-grants-2006_07
Patent number
US07071182B2

Reaction notes

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