反应详情

According to the procedure for Example 49, 1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-ylamine and [5-(2-p-tolylsulfanyl-acetyl)-thiophen-2-yl]-acetic acid were processed to provide the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 1.82 (m, 2 H), 1.98 (m, 2 H), 2.25 (s, 3 H), 3.02 (m, 2 H), 3.52 (m, 2 H), 3.70 (q, J=5.80 Hz, 2 H), 4.05 (s, 2 H), 4.41 (s, 2 H), 4.68 (t, J=6.26 Hz, 2 H), 7.12 (m, 4 H), 7.26 (m, 2 H), 7.74 (m, 1 H), 7.94 (m, 1 H), 8.11 (s, 1 H), 8.27 (s, 1 H), 9.56 (br s, N H); MS (DCI/NH3) m/z 519 (M+H)+.