1-(2-Pyrrolidin-1-YL-ethyl)-1H-indazol-6-ylamine → HCID 22036584, compound

HRID 1790135Notes

Reaction equation

HRID 1790135 reaction equation
[N:1]1([CH2:6][CH2:7][N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([NH2:17])[CH:15]=3)[CH:10]=[N:9]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[O:18]([C:25]1[CH:30]=[CH:29][N:28]=[CH:27][C:26]=1[CH:31]=[CH:32][C:33](O)=[O:34])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[O:18]([C:25]1[CH:30]=[CH:29][N:28]=[CH:27][C:26]=1/[CH:31]=[CH:32]/[C:33]([NH:17][C:14]1[CH:15]=[C:16]2[C:11]([CH:10]=[N:9][N:8]2[CH2:7][CH2:6][N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:12][CH:13]=1)=[O:34])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 112762881-(2-Pyrrolidin-1-YL-ethyl)-1H-indazol-6-ylamineHCID 69652772HCID 69652772, compound

Product 1

HCID 22036584HCID 22036584, compound

Procedure

According to the procedure for Example 49, 1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-ylamine and 3-(4-phenoxy-pyridin-3-yl)-acrylic acid were processed to provide the title compound. MS (DCI/NH3) MS m/z 454 (M+H)+; 1H NMR (500 MHz, DMSO-d6) δ ppm 1.84 (m, 2 H), 2.01 (m, 2 H), 3.07 (m, 2 H), 3.54 (m, 2 H), 3.73 (m, 2 H), 4.71 (t, J=6.08 Hz, 2 H), 6.88 (m, 1 H), 7.20 (m, 5 H), 7.45 (m, 2 H), 7.62 (m, 1 H), 7.75 (m, 1 H), 8.13 (m, 2 H), 8.40 (m, 2 H), 9.62 (br s, N H).

Sources & evidence

ORD record
ord-cc5c29f210144d808a5adb1b9f887bc5
Source dataset
uspto-grants-2006_07
Patent number
US07071182B2

Reaction notes

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