HCID 11612403, compound → HCID 11518384, compound

Participants

Reaction Steps

1-(4-phenoxyphenyl)-3-[1-(2-pyrrolidin-1-ylethyl)-1H-indazol-5-yl]-1,3-dihydro-2H-imidazol-2-one (Example 118) (0.100 g, 0.215 mmol) was dissolved in 20 mL of AcOH and 100 mg of Pd/C (10% mol/mol) was added. The mixture was subjected to an atmosphere of hydrogen gas at a pressure of 60 psi in a Parr shaker apparatus, and shaken at room temperature for 6 hours. The mixture was filtered through celite, and the solvents removed under reduced pressure. The residue was purified by RP-HPLC to provide the title compound. 1H NMR (300 MHz, DMSO-D6) δ ppm 1.52–1.77 (m, 4 H) 2.34–2.50 (m, 4 H) 2.87 (t, J=6.61 Hz, 2 H) 3.88–4.13 (m, 4 H) 4.50 (t, J=6.61 Hz, 2 H) 6.93–7.02 (m, J=7.80 Hz, 2 H) 7.03–7.15 (m, 3 H) 7.33–7.45 (m, J=8.65, 7.29 Hz, 2 H) 7.61–7.72 (m, 3 H) 7.72–7.78 (m, J=2.03 Hz, 1 H) 7.79–7.89 (m, 1 H) 8.02 (s, 1 H); MS (ESI) m/z 468 [M+H]+.

Provenance & Evidence