反应详情

To a solution of 2-nitro-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene (79.0 g, 0.339 mol) in dichloromethane as added 1 g of 10% palladium on carbon and the mixture was hydrogenated at 40–50 psi of hydrogen for 20 hrs. The catalyst was removed by filtration and the organic and the aqueous layers were separated. The aqueous layer was made alkaline by addition of 1N NaOH and extracted with dichloromethane. The combined organic phases were dried over sodium sulfate, filtered and evaporated to give 2-amino-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene as a red-orange solid which was used in the next step without further purification.

1. customThe catalyst was removed by filtration
2. customthe organic and the aqueous layers were separated
3. additionby addition of 1N NaOH
4. extractionextracted with dichloromethane
5. dry with materialThe combined organic phases were dried over sodium sulfate
6. filtrationfiltered
7. customevaporated