反应详情

Into a mixed solvent of 30 mL of methanol and 30 mL of dioxane was dissolved 640 mg of 5% palladium/carbon, followed by 10 minutes of stirring under a hydrogen atmosphere. Under an argon atmosphere, 330 mg of Compound 1 was added, followed by 3 days of stirring under a hydrogen atmosphere at 5 atm. After confirmation of disappearance of the starting material, the reaction mixture was filtered and purified by silica gel column chromatography (ethyl acetate/hexane=2/1) to obtain 70 mg of the title compound as colorless powder.

1. waitfollowed by 3 days
2. stirringof stirring under a hydrogen atmosphere at 5 atm
3. filtrationAfter confirmation of disappearance of the starting material, the reaction mixture was filtered
4. custompurified by silica gel column chromatography (ethyl acetate/hexane=2/1)