HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 22041552, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 22041505 | HCID 22041505 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22041552 | HCID 22041552 | — |
Reaction Steps
Dissolve the compound obtained in Step C of Example 10 (1 eq.) and CH3I (2 eq.): in 55 ml of anhydrous DMF and place in an ice bath at 0° C. Add NaH (1.5 eq.) in portions. Allow to return to ambient temperature. Hydrolyse, acidify with 1N HCl and filter. Purify the resulting crude product by chromatography on silica gel (eluant:diethyl ether/toluene 2/8).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071221B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-860dedf2fc534956b98b8e133ac89c91 |
| Source note | uspto-grants-2006_07 |