Nitroethane → HCID 69621553, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the product from Step A (0.8 g, 2.93 mmol) in nitroethane (10 mL) was added ammonium acetate (0.45 g, 5.84 mmol). The mixture was stirred at 60° C. overnight. The excess nitroethane was removed and the residue purified by flash chromatography (silica gel, ethyl acetate/hexane: 0.5/9.5) to give 0.5 g of a yellow solid: 1H NMR (DMSO-d6) δ 2.45 (s, 3H, CH3), 3.84 (s, 3H, OCH3), 4.00 (s, 3H, OCH3), 6.95 (s, 1H, Ar—H), 7.65 (m, 2H, Ar—H), 8.10 (m, 2H, Ar—H), 8.29 (s, 1H, CH═).

Provenance & Evidence