Methanol → Methyl 5-bromopyridine-3-carboxylate

HRID 1790385Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH3:11]O>>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([O:9][CH3:11])=[O:8]

Participants

Reactant 2

HCID 887Methanol

HCID 887075-Bromonicotinic acid

Product 1

HCID 699336Methyl 5-bromopyridine-3-carboxylateYield 94%

Procedure

5-Bromonicotinic acid (10 g) and methanol were treated as in the above Production Example 3-3 to give the title compound (10.052 g) as colorless crystals (yield: 94.0%).

Sources & evidence

ORD record: ord-b40d176e5f5443f48ab327e972bbd53b
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07071201B2

Reaction notes

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