反应详情

1-(2-Benzyloxyethyl)-4-bromopyrazole (1.078 g) was dissolved in ethanol (20 ml). After adding conc. hydrochloric acid (15 ml), the resultant mixture was stirred at 80° C. for 10 hr. After allowing to cool, it was concentrated under reduced pressure followed by the addition of a saturated aqueous solution of sodium bicarbonate. Then the resultant mixture was extracted with ethyl acetate and the organic layer was washed with water, dried over magnesium sulfate and concentrated under reduced pressure to give the title compound (525 mg) as a colorless oil (yield: 71%).

1. temperatureto cool
2. concentrationit was concentrated under reduced pressure
3. additionfollowed by the addition of a saturated aqueous solution of sodium bicarbonate
4. extractionThen the resultant mixture was extracted with ethyl acetate
5. washthe organic layer was washed with water
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated under reduced pressure