HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → tert-Butyl [2-(hydroxymethyl)phenyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 22038324 | HCID 22038324 | — |
| Product | tert-Butyl [2-(hydroxymethyl)phenyl]carbamate | HCID 15292992 | 79% |
Reaction Steps
1-(t-Butoxy)carbonyl-3-(4-fluorophenyl)indole (0.340 g) was freed from the protecting group with the use of trifluoroacetic acid and then treated as in the above Production Example 54 to give the title compound (0.184 g) as a pale yellow oil (yield: 79.0%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071201B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-c9e0bf59611b4d53886e3cc23206e4cf |
| Source note | uspto-grants-2006_07 |