Indole-3-Carboxaldehyde → HCID 69593693, compound

HRID 1790395Notes

Reaction equation

HRID 1790395 reaction equation
[CH:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]=1)=O.[Cl-].[F:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=1)[CH2:17][PH3+]>>[F:13][C:14]1[CH:15]=[C:16]([CH:17]=[CH:1][C:3]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[NH:5][CH:4]=2)[CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 10256Indole-3-CarboxaldehydeHCID 22038339HCID 22038339, compound

Product 1

HCID 69593693HCID 69593693, compoundYield 73.1%

Procedure

3-Formylindole (1.0 g) and 3-fluorobenzylphosphonium chloride (2.8 g) were treated as in the above Production Example 41-1 to give the title compound (0.598 g) as colorless crystals (yield: 73.1%).

Sources & evidence

ORD record
ord-c567076c452241ecb7e57b0176766525
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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