1-Piperidin-4-yl-2,3-dihydro-1H-indole → 1-[1-(4-Methanesulfonylphenethyl)piperidin-4-yl]indoline

HRID 1790404Notes

Reaction equation

HRID 1790404 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[CH3:16][S:17]([C:20]1[CH:28]=[CH:27][C:23]([CH2:24][CH2:25]Br)=[CH:22][CH:21]=1)(=[O:19])=[O:18]>>[CH3:16][S:17]([C:20]1[CH:28]=[CH:27][C:23]([CH2:24][CH2:25][N:1]2[CH2:6][CH2:5][CH:4]([N:7]3[C:15]4[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=4)[CH2:9][CH2:8]3)[CH2:3][CH2:2]2)=[CH:22][CH:21]=1)(=[O:18])=[O:19]

Participants

3

Reactant 2

HCID 220286031-Piperidin-4-yl-2,3-dihydro-1H-indoleHCID 22037895HCID 22037895, compound

Product 1

HCID 220380481-[1-(4-Methanesulfonylphenethyl)piperidin-4-yl]indolineYield 47.3%

Procedure

1-(Piperidin-4-yl)indoline (200 mg) and 4-methane-sulfonylphenethyl bromide (290 mg) were treated as in Example 2 to give the title compound (180 mg) as a white powder (yield: 43%).

Sources & evidence

ORD record
ord-956123743f00448098c5eda3eb046329
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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