Propionyl chloride → HCID 22038407, compound

HRID 1790413Notes

Reaction equation

[NH2:1][CH2:2][C:3]1[CH:26]=[CH:25][C:6]([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([N:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH:17]([CH3:24])[CH2:16]3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[C:27](Cl)(=[O:30])[CH2:28][CH3:29]>>[C:27]([NH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([N:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH:17]([CH3:24])[CH2:16]3)[CH2:11][CH2:10]2)=[CH:25][CH:26]=1)(=[O:30])[CH2:28][CH3:29]

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 22038376HCID 22038376, compound

Product 1

HCID 22038407HCID 22038407, compound

Procedure

1-[1-(4-Aminomethylphenethyl)piperidin-4-yl]-3-methylindoline (0.1 g) and propionyl chloride (0.028 ml) were treated as in Example 36 to give the title compound (0.122 g) as a pale yellow oil (yield: quantitative).

Sources & evidence

ORD record: ord-1a7c18596ed54aedaf32d9601c726b6d
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07071201B2

Reaction notes

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