HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Piperidin-4-yl-2,3-dihydro-1H-indole → 1-{1-[3-(4-Hydroxymethylphenoxy)propyl]piperidin-4-yl}indoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Piperidin-4-yl-2,3-dihydro-1H-indole | HCID 22028603 | — |
| Reactant | (4-(3-Bromopropoxy)phenyl)methanol | HCID 23377467 | — |
| Product | 1-{1-[3-(4-Hydroxymethylphenoxy)propyl]piperidin-4-yl}indoline | HCID 22038387 | 92% |
Reaction Steps
1-(4-Piperidyl)indoline (263 mg) and 4-(3-bromopropoxy)benzyl alcohol (389 mg) were treated as in Example 2 to give the title compound (422 mg) as a pale orange amorphous solid (yield: 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071201B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-b76d243ab5e244ce93d72c604ae26413 |
| Source note | uspto-grants-2006_07 |