Ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride → 3-Piperidinecarboxylic acid, 4-oxo-, ethyl ester, hydrochloride (1:1)

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Reaction Steps

10% palladium/active carbon (2 g) was added to a solution of ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride (30 g) in methanol (500 ml) and the resultant mixture was stirred at room temperature under hydrogen atmosphere for a day. After filtering the reaction mixture through celite, the filtrate was concentrated under reduced pressure to give the title compound (20.0 g) as a white powder (yield: 97%).

Provenance & Evidence