4-Fluorophenethyl bromide → HCID 22038123, compound

HRID 1790441Notes

Reaction equation

HRID 1790441 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([N+:16]([O-:18])=[O:17])[CH:14]=3)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[F:19][C:20]1[CH:28]=[CH:27][C:23]([CH2:24][CH2:25]Br)=[CH:22][CH:21]=1>>[F:19][C:20]1[CH:28]=[CH:27][C:23]([CH2:24][CH2:25][N:1]2[CH2:6][CH2:5][CH:4]([N:7]3[C:15]4[C:10](=[CH:11][CH:12]=[C:13]([N+:16]([O-:18])=[O:17])[CH:14]=4)[CH2:9][CH2:8]3)[CH2:3][CH2:2]2)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 5731534-Fluorophenethyl bromideHCID 22037978HCID 22037978, compound

Product 1

HCID 22038123HCID 22038123, compoundYield 97.5%

Procedure

1-(Piperidin-4-yl)-6-nitroindoline (3.5 g) and 4-fluorophenethyl bromide (4.1 g) were treated as in Example 2 to give the title compound (5.1 g) as apaleyellowpowder (yield: 81%).

Sources & evidence

ORD record
ord-8b3e73ec0c7140a8b321f36640b8abab
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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