2-Fluorophenethyl bromide → 1-[1-(2-Fluorophenethyl)piperdin-4-yl]-6-acetamidomethylindoline

HRID 1790450Notes

Reaction equation

HRID 1790450 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([CH2:16][NH:17][C:18](=[O:20])[CH3:19])[CH:14]=3)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[F:21][C:22]1[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=1[CH2:24][CH2:25]Br>>[F:21][C:22]1[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=1[CH2:24][CH2:25][N:1]1[CH2:2][CH2:3][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([CH2:16][NH:17][C:18](=[O:20])[CH3:19])[CH:14]=3)[CH2:9][CH2:8]2)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 27569642-Fluorophenethyl bromideHCID 220382751-(Piperidin-4-yl)-6-acetamidomethylindoline

Product 1

HCID 220380851-[1-(2-Fluorophenethyl)piperdin-4-yl]-6-acetamidomethylindolineYield 52.5%

Procedure

1-(Piperidin-4-yl)-6-acetamidomethylindoline (250 mg) and 2-fluorophenethyl bromide (220 mg) were treated as in Example 2 to give the title compound (190 mg) as a whitepowder (yield: 52%).

Sources & evidence

ORD record
ord-d10a9493fdcc4556bbcc37962679dd8c
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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