HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → 1-[1-(4-Fluorophenethyl)-piperidin-4-yl]-6-(cyclopropylcarbamoylmethyl)indoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-carboxymethylindoline | HCID 22038043 | — |
| Product | 1-[1-(4-Fluorophenethyl)-piperidin-4-yl]-6-(cyclopropylcarbamoylmethyl)indoline | HCID 22037894 | 40% |
Reaction Steps
1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-carboxymethylindoline (250 mg), 1,1′-carbonyldiimidazole (130 mg) and cyclopropylamine (45 mg) were treated as in Example 151 to give the title compound (110 mg) as a white powder (yield: 40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071201B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-c4b8544b77384950aec80f4d618c1cc6 |
| Source note | uspto-grants-2006_07 |