2-(Tributylstannyl)-1,3-thiazole → HCID 22038303, compound

HRID 1790462Notes

Reaction equation

HRID 1790462 reaction equation
[F:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20](Br)[CH:21]=4)[CH2:16][CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.C([Sn](CCCC)(CCCC)[C:31]1[S:32][CH:33]=[CH:34][N:35]=1)CCC>>[F:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([C:31]5[S:32][CH:33]=[CH:34][N:35]=5)[CH:21]=4)[CH2:16][CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27632592-(Tributylstannyl)-1,3-thiazoleHCID 220378891-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-bromoindoline

Product 1

HCID 22038303HCID 22038303, compoundYield 3%

Procedure

1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-bromoindoline (0.56 g) and 2-tributylstannylthiazole (2.778 g) synthesized in accordance with the method described in Synthesis, 757 (1986). were treated as in Production Example 13-2 to give the title compound (0.017 g) as pale yellow crystals (yield: 3.0%).

Workup

  1. customdescribed in Synthesis, 757 (1986)
  2. additionwere treated as in Production Example 13-2

Sources & evidence

ORD record
ord-ece830a4cf254389874be2a399685014
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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