6-Methoxy-1-Indanone → HCID 12374669, compound

6-Methoxyindan-1-one (5.0 g) was dissolved in methanol (50 ml). Next, sodium tetrahydroborate (1.41 g) was added thereto at 0° C., and the resultant mixture was reacted at room temperature for 5 hr. The reaction solution was concentrated under reduced pressure and the residue was partitioned between ethyl acetate and water. The ethyl acetate layer was washed with water, dried and concentrated under reduced pressure to give 6-methoxyindan-1-ol (5.1 g) as an oil. This alcohol was not purified but reacted as such with thionyl chloride (4.5 ml) in ether at room temperature for 6 hr. The reaction solution was poured into ice water and extracted with ether. The ether layer was washed with water, dried and concentrated under reduced pressure to give the title compound (2.76 g). (251-2) 1-(4-Acetylpiperazin-1-yl)-6-methoxyindan

1. concentrationThe reaction solution was concentrated under reduced pressure
2. customthe residue was partitioned between ethyl acetate and water
3. washThe ethyl acetate layer was washed with water
4. customdried
5. concentrationconcentrated under reduced pressure

ORD record

ord-5560cc829e98483ca2ad1691a83b6d91

Source dataset

uspto-grants-2006_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07071201B2