1-(2-Bromoethyl)-4-methoxybenzene → HCID 22038289, compound

HRID 1790483Notes

Reaction equation

HRID 1790483 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([Cl:16])[N:14]=3)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[CH3:17][O:18][C:19]1[CH:27]=[CH:26][C:22]([CH2:23][CH2:24]Br)=[CH:21][CH:20]=1>>[CH3:17][O:18][C:19]1[CH:27]=[CH:26][C:22]([CH2:23][CH2:24][N:1]2[CH2:2][CH2:3][CH:4]([N:7]3[C:15]4[C:10](=[CH:11][CH:12]=[C:13]([Cl:16])[N:14]=4)[CH2:9][CH2:8]3)[CH2:5][CH2:6]2)=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 844271-(2-Bromoethyl)-4-methoxybenzeneHCID 220382871-(Piperidin-4-yl)-6-chloro-7-azaindoline

Product 1

HCID 22038289HCID 22038289, compoundYield 16%

Procedure

1-(Piperidin-4-yl)-6-chloro-7-azaindoline (0.8 g) and 4-methoxyphenethyl bromide (0.72 g) were treated as in Example 2 to give the hydrochloride (220 mg) of the title compound as a pale yellow powder (yield: 16%).

Sources & evidence

ORD record
ord-ae8a87a35cf14a7cb905b3da0891fd3a
Source dataset
uspto-grants-2006_07
Patent number
US07071201B2

Reaction notes

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