HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(4-Fluorophenyl)ethyl]piperidin-4-one → 6-bromo-3,3-dimethyl-2,3-dihydro-1H-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(4-Fluorophenyl)ethyl]piperidin-4-one | HCID 7023594 | — |
| Reactant | 6-Bromo-3,3-dimethylindoline | HCID 10704410 | — |
| Product | 6-bromo-3,3-dimethyl-2,3-dihydro-1H-indol-2-one | HCID 10657649 | 89.2% |
Reaction Steps
3,3-Dimethyl-6-bromoindoline (3.10 g), 1-[2-(4-fluorophenyl)ethyl]-4-piperidone (2.81 g) and triacetoxylated sodium borohydride (5.70 g) were treated as in Example 16 to give the title compound (2.72 g) as a white amorphous solid (yield: 49.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071201B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-f23be0e308a34927aa7afcab7bc48bcb |
| Source note | uspto-grants-2006_07 |