反应详情

温度

50 °C

A suspension of 1-[1-(4-fluorophenethyl)piperidin-4-yl]-6-(ethylcarbamoylmethyl)indoline (0.41 g) obtained in Example 149 and active manganese dioxide (0.40 g) in chloroform (30 ml) was vigorously stirred at 50° C. for 6 hr. Then the reaction mixtures were filtered through celite and the residue was washed with chloroform. After concentrating the filtrate under reduced pressure, the residue was recrystallized from chloroform/hexane to give the title compound (0.33 g) as white needles (yield: 89.5%).

1. customThen the reaction mixtures
2. filtrationwere filtered through celite
3. washthe residue was washed with chloroform
4. concentrationAfter concentrating the filtrate under reduced pressure
5. customthe residue was recrystallized from chloroform/hexane