Bromine → 2-Bromo-4-ethylphenol

HRID 1790558Notes

Reaction equation

HRID 1790558 reaction equation
[Br:1]Br.[CH2:3]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)[CH3:4]>C(Cl)(Cl)Cl.CO>[Br:1][C:7]1[CH:6]=[C:5]([CH2:3][CH3:4])[CH:10]=[CH:9][C:8]=1[OH:11]

Participants

5

Reactant 2

HCID 24408BromineHCID 312424-Ethylphenol

Product 1

HCID 166412522-Bromo-4-ethylphenol

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6212ChloroformSolvent

Procedure

8.41 ml of bromine in 100 ml of CHCl3 were added dropwise within 2 hrs. to a solution, cooled to 0° C., of 20 g of 4-ethylphenol in 200 ml of CHCI3 and 100 ml of MeOH. The reaction mixture was left to warm to room temperature and was concentrated. The product was isolated by extraction. There were obtained 33.14 g of 2-bromo-4-ethyl-phenol as a light brown oil.

Workup

  1. waitThe reaction mixture was left
  2. concentrationwas concentrated
  3. customThe product was isolated by extraction

Sources & evidence

ORD record
ord-ce3b51218d7a4b3ea8639ec7b67345cb
Source dataset
uspto-grants-2006_07
Patent number
US07071212B2

Reaction notes

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