HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 4-(3-Pyrrolidinylpropoxy)benzene-1,2-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | {4-[2-Methoxy-4-(methylamino)-5-nitrophenoxy] (2-pyridyl)}-n-methylcarboxamide | HCID 131725843 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 4-(3-Pyrrolidinylpropoxy)benzene-1,2-diamine | HCID 21037292 | — |
Reaction Steps
To a solution 2-Nitro-4-(3-pyrrolidinylpropoxy)phenylamine 1 in EtOH, Pd/C (0.1 eq) is added. The reaction vessel is repeatedly purged (×3) with nitrogen, and then stirred under a hydrogen atmosphere for 18 h. The product is filtered through a Celite plug, and the plug washed with 25 mL of EtOH, to yield 2. LCMS 236.2 Rt 0.94 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071216B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-d83a7c5eff9f4444938f5ef737900e22 |
| Source note | uspto-grants-2006_07 |