HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 4-[1-Methyl-2-(3-phenoxy-phenylamino)-1h-benzoimidazol-5-yloxy]-pyridine-2-carboxylic acid methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 3-Phenoxyphenylisothiocyanate | HCID 22041281 | — |
| Reactant | {4-[2-Methoxy-4-(methylamino)-5-nitrophenoxy] (2-pyridyl)}-n-methylcarboxamide | HCID 131725843 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[1-Methyl-2-(3-phenoxy-phenylamino)-1h-benzoimidazol-5-yloxy]-pyridine-2-carboxylic acid methylamide | HCID 21037362 | — |
Reaction Steps
A 1 dram vial was charged with a solution of 3-phenoxyphenylisothiocyanate (23 mg, 0.1 mmol), diamine 1 (27 mg, 0.1 mmol), and MeOH (0.5 mL) and the reaction was shaken at rt overnight. Methyl iodide (8 uL, 0.13 mmol) was added and the mixture shaken overnight. The reaction was concentrated and the resulting residue purified on reverse phase HPLC. LCMS m/z 466.3 (MH+), tR=2.40 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071216B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-9dd8ff5a8b8b41219f159bbebd81ad04 |
| Source note | uspto-grants-2006_07 |