Hydrochloric Acid → Oxycodone Hydrochloride

Participants

Reaction Steps

8.1 g of oxycodone obtained in Example 15 and 80 ml of ethanol are placed in a 250 ml round-bottomed flask. The mixture is heated to reflux. Into the hot mixture is added 10 ml of a concentrated solution of hydrogen chloride in isopropanol. The mixture is cooled and stirred at 0–5° C. for 1–2 hours. The product is filtered off and the filter cake is washed with a small amount of cold ethanol. After drying in vacuo (e.g., 50 mm Hg) at 30–40° C., 7.7 g (85% yield) of pure oxycodone hydrochloride is obtained.

Provenance & Evidence