Formamidine acetate → HCID 22042239, compound

Participants

Reaction Conditions

Reaction Steps

N1-[8-(tert-Butyl-dimethyl-silanyloxy)-quinolin-2-yl]-4-methoxy-benzene-1,2-diamine D (18.3 g, 46.1 mmol) was dissolved in 40 mL of 2-methoxyethanol under an atmosphere of dry N2. To this solution was added formamidine acetate (5.28 g, 50.7 mmol) and the reaction mixture was heated to 125° C. and reacted at this temperature for 1.5 hours. The solvent was removed under vacuum and the resulting solid was triturated with ethyl ether (Et2O), dried under vacuum to give 13.3 g of E as a pink solid.

Provenance & Evidence