Propylene Oxide → Gabapentin
反応式
[CH2:1]1[CH2:6][CH2:5][C:4]([CH2:11][NH2:12])([CH2:7][C:8]([OH:10])=[O:9])[CH2:3][CH2:2]1.Cl.C1OC1C>C(O)CCC>[CH2:1]1[CH2:2][CH2:3][C:4]([CH2:11][NH2:12])([CH2:7][C:8]([OH:10])=[O:9])[CH2:5][CH2:6]1参加物
4
反応条件
- 温度
- -5 °C
実験手順
Gabapentin hydrochloride (72 mmol) was suspended in 50 mL of n-butanol and heated gently until complete dissolution. The solution was cooled below 10° C. and propylene oxide (144 mmol) was added in one portion. The mixture was stirred for 16 hours below 10° C., after which it was cooled to −5° C. Pure gabapentin was recovered by filtration and washed with cold isopropanol. Drying at 40–50° C. under reduced pressure afforded 11.1 g of pure gabapentin.
後処理
- temperatureheated gently until complete dissolution
- temperatureThe solution was cooled below 10° C.
- filtrationPure gabapentin was recovered by filtration
- washwashed with cold isopropanol
- customDrying at 40–50° C. under reduced pressure
出典と根拠
- ORDレコード
- ord-e5fbcb393acc42a0a03ec4ab307019b7
- 出典データセット
- uspto-grants-2006_07
- 特許番号
- US07071356B1
反応ノート
読み込み中…