1,2-Epoxybutane → Gabapentin

Participants

Reaction Conditions

Reaction Steps

Gabapentin hydrochloride (72 mmol) was suspended in 50 mL of n-butanol and heated gently until complete dissolution. The solution was cooled below 10° C. and 1,2-epoxybutane (144 mmol) was added in one portion. The mixture was stirred for 16 hours below 10° C., after which it was cooled to −5° C. Pure gabapentin was recovered by filtration and washed with cold isopropanol. Drying at 40–50° C. under reduced pressure afforded 9.4 g of pure gabapentin.

Provenance & Evidence