HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5-carboxymethoxy-1H-indole-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 5-tert-butoxycarbonylmethoxy-1H-indole-2-carboxylic acid ethyl ester | HCID 69587439 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-carboxymethoxy-1H-indole-2-carboxylic acid ethyl ester | HCID 69586665 | 101.3% |
Reaction Steps
A mixture of 5-tert-butoxycarbonylmethoxy-1H-indole-2-carboxylic acid ethyl ester (2 g, 6 mmol) and trifluoroacetic acid (8 mL) in dichloromethane (8 mL) was stirred at room temperature for 2 hours. The reaction was concentrated to give 1.6 g (97%) of 5-carboxymethoxy-1H-indole-2-carboxylic acid ethyl ester as a light brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071332B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-1cd0dafad4d04a1f958e81fb95affc08 |
| Source note | uspto-grants-2006_07 |