HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 5-Bromo-3-[5-(2-pyrrolidin-1-yl-ethoxy)-1H-indol-2-ylmethylene]-1,3-dihydro-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 5-Bromo-2-oxindole | HCID 611193 | — |
| Reactant | 5-(2-pyrrolidin-1-yl-ethoxy)-1H-indole-2-carbaldehyde | HCID 22042092 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Bromo-3-[5-(2-pyrrolidin-1-yl-ethoxy)-1H-indol-2-ylmethylene]-1,3-dihydro-indol-2-one | HCID 69586819 | 80% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 5-bromo-2-oxindole (42 mg, 0.2 mmol), 5-(2-pyrrolidin-1-yl-ethoxy)-1H-indole-2-carbaldehyde (52 mg, 0.2 mmol) and piperidine (0.1 mL) in ethanol (1 mL) was heated at 100° C. for 2 hours. The precipitate was collected by vacuum filtration, washed with ethanol and dried to give 72 mg (80%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071332B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-de55be6c638c4f83869efa1708c29f03 |
| Source note | uspto-grants-2006_07 |