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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1790929Generated: October 25, 2026

Piperidine → 3-[5-(2-Diethylamino-ethoxy)-1H-indol-2-ylmethylene]-5-phenyl-1,3-dihydro-indol-2-one

https://huagongshe.com/reaction/1790929

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperidineHCID 8082—
Reactant5-PhenyloxindoleHCID 13301978—
ReactantHCID 22042099HCID 22042099—
SolventEthanolHCID 702—
Product3-[5-(2-Diethylamino-ethoxy)-1H-indol-2-ylmethylene]-5-phenyl-1,3-dihydro-indol-2-oneHCID 6958698054.1%

Reaction Conditions

Temperature100 °C

Reaction Steps

A mixture of 5-phenyl-2-oxindole (39 mg, 0.18 mmol), 5-(2-diethylamino-ethoxy)-1H-indole-2-carbaldehyde (48 mg, 0.18 mmol) and piperidine (0.1 mL) in ethanol (1 mL) was heated at 100° C. for 2 hours. The precipitate was collected by vacuum filtration, washed with ethanol and dried to give 44 mg (54%) of the title compound as a red solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07071332B2
Source datasetuspto-grants-2006_07
ORD IDord-43bbeb0308db46c6a1084da79f6862e9
Source noteuspto-grants-2006_07