HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → N-[(4-fluorophenyl)methyl]-2-oxo-1,3-dihydroindole-5-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-Fluorobenzylamine | HCID 67326 | — |
| Reactant | 2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride | HCID 4962506 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[(4-fluorophenyl)methyl]-2-oxo-1,3-dihydroindole-5-sulfonamide | HCID 9266705 | 84% |
Reaction Steps
A suspension of 5-chlorosulfonyl-2-oxindole (5.0 g), 4-fluorobenzylamine (3.0 mL) and pyridine (3.5 mL) in dichloromethane (30 mL) was stirred at room temperature for 4 hours. The precipitate was filtered, washed with dichloromethane and dried to give 5.8 g (84%) of 2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid 4-fluoro-benzylamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071332B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-b80eeb8993cb48e39afe93a6e754ca1a |
| Source note | uspto-grants-2006_07 |