Benzenesulfonyl chloride → HCID 22042629, compound

HRID 1791004Notes

Reaction equation

FCC(CF)(CF)[C:4]([C:16]1[CH:21]=[CH:20][C:19]([NH:22][CH3:23])=[C:18]([CH3:24])[CH:17]=1)([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1)[OH:5].[C:29]1([S:35](Cl)(=[O:37])=[O:36])[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH3:23][N:22]([C:19]1[CH:20]=[CH:21][C:16]([C:4]([OH:5])([C:6]2[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=2)[C:12]([F:15])([F:14])[F:13])=[CH:17][C:18]=1[CH3:24])[S:35]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)(=[O:37])=[O:36]

Participants

Reactant 2

HCID 7369Benzenesulfonyl chloride

HCID 86605316HCID 86605316, compound

Product 1

HCID 22042629HCID 22042629, compound

Procedure

The title compound was prepared from 2,2,2-trifluoromethyl-1-(3-methyl-4-methylaminophenyl)-1-(3-trifluoromethyl-phenyl)-ethanol (Step A) and benzenesulfonyl chloride using the procedure described in Example 1, Step D. 1H-NMR (CDCl3) δ 2.41 (s, 3H), 3.15 (s, 3H), 6.64 (d, J=8.4 Hz, 1H), 7.18 (brs, 1H), 7.42 (brs, 1H), 7.52–7.56 (m, 3H), 7.63–7.67 (m, 3H), 7.73 (d, J=8.5 Hz, 2H), 7.82 (s, 1H). Mass Spectrum (CI+) m/e=526.0 (M+23).

Sources & evidence

ORD record: ord-5753627b79654a82b0b98a7cd4b39a1f
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07071358B2

Reaction notes

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