Tetrabutylammonium Fluoride → HCID 22042620, compound

Participants

Reaction Steps

To a solution of 0.25 g (0.51 mmol) of N-[4-(1-hydroxy-1-trifluoromethyl-3-trimethylsilanyl-prop-2-ynyl)-phenyl]-N-isobutyl-benzenesulfonamide (Example 74) in 6 mL of CH2Cl2 was added 0.4 mL of a 1 M solution of tetrabutylammonium fluoride in THF. The mixture was stirred at room temperature for 1 hour. CH2Cl2 (60 mL) was added and the solution was washed with saturated aqueous NH4Cl-solution (20 mL) and brine (15 mL). The organic layer was dried over Na2SO4, filtered and the filtrate was concentrated. The residue was purified by chromatography on silica gel, (hexane:EtOAc, 7:3) to give the title compound.

Provenance & Evidence