Methanol → HCID 73861445, compound

HRID 1791051Notes

Reaction equation

HRID 1791051 reaction equation
[CH3:1][NH:2][OH:3].[CH3:4][N:5]([CH3:20])[C:6]([C:8]1[CH:9]=[CH:10][C:11]2[O:17][CH2:16]C(=O)[CH:14]=[CH:13][C:12]=2[CH:19]=1)=[O:7].[CH3:21]O>>[CH3:21][O:3][N:2]=[C:1]1[CH:14]=[CH:13][C:12]2[CH:19]=[C:8]([C:6]([N:5]([CH3:20])[CH3:4])=[O:7])[CH:9]=[CH:10][C:11]=2[O:17][CH2:16]1

Participants

4

Reactant 3

HCID 887MethanolHCID 11647MethylhydroxylamineHCID 22042261HCID 22042261, compound

Product 1

HCID 73861445HCID 73861445, compoundYield 38%

Procedure

37 mg of N-methylhydroxylamine are added to 150 mg (0.65 mmol) of N,N-dimethyl-3-oxo-2,3-dihydro-1-benzoxepin-7-carboxamide, prepared according to example 53, in solution in 1 ml of methanol, and the medium is stirred at ambient temperature for 2 hours. After evaporating the methanol, followed by the conventional treatments, the crude product is purified to provide 65 mg (38%) of 3-(methoxyimino)-N,N-dimethyl-2,3-dihydro-1-benzoxepin-7-carboxamide, as an equimolecular mixture of the E and Z isomers, in the form of a yellow oil:mass (APCI) M+1:261

Workup

  1. customprepared
  2. customAfter evaporating the methanol
  3. customthe crude product is purified

Sources & evidence

ORD record
ord-954ff43e90644cdc809fe4fa5bee8c9a
Source dataset
uspto-grants-2006_07
Patent number
US07071340B2

Reaction notes

Loading…